Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases

Abstract

Key PointsColony-stimulating factors (CSFs) are pleiotropic, but each has its own unique biological role.All CSFs control myeloid cell numbers, but each has a level of specificity in regard to its target cells and effects.Preclinical and/or clinical data suggest that targeting granulocyte–macrophage CSF (GM-CSF), CSF1, granulocyte CSF (G-CSF) or IL-3 could be useful in the treatment of numerous autoimmune and/or inflammatory pathologies, including rheumatoid arthritis and multiple sclerosis. Further investigation of the potential of targeting CSFs in other pathologies is warranted.CSF targeting, as well as associated patient stratification, should be based on the specific CSF biology.There i..